cxc chemokine receptors — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1955	SB225002		CXCR
	SB225002 is a potent and selective CXCR2 antagonist inhibiting interleukin IL-8 binding to CXCR2.		CXCR
T3047	SRT3109		CXCR
	SRT3109 is a CXCR2 ligand used in the treatment of chemokine mediated diseases and conditions.		CXCR
T7681	AZD-5069		CXCR
	AZD-5069 is an chemokine receptor 2 antagonist (CXCR2; IC50 = 0.79 nM).		CXCR
T1739	WZ811		CXCR
	WZ811 is a novel and effective small molecular CXCR4 antagonist (EC50: 0.3 nM).		CXCR
T4163	Reparixin	DF 1681Y,Repertaxin	CXCR
	Reparixin (Repertaxin) is a potent inhibitor of both CXCL8 receptors CXCR1/2, it inhibits weakly CXCR2-mediated cell migration (IC50=100 nM), whereas it strongly blocks CXCR1-mediated chemotaxis (IC50=1 nM).		CXCR
T3992	MSX-122	MSX 122,MSX122	CXCR
	MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions(IC50 = 10 nM).		CXCR
T17208	USL311		CXCR
	USL311 is a CXCR4 receptor antagonist which prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4. USL311 inhibits CXCR4 activation and decreases proliferation and migration of CXCR4-expressing...		CXCR
T5193	Danirixin	GSK1325756	CXCR
	Danirixin (GSK1325756) is a potent antagonist of CXCR2 that inhibits IL-8 binding to CXCR2 (IC50: 12.5 nM).		CXCR
T10297L	AMG 487		CXCR
	AMG 487 is a potent and selective antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively.		CXCR
T2477	UNBS5162	UNBS 5162,UNBS-5162	CXCR , Autophagy
	UNBS5162 (UNBS-5162) is a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers.		CXCR , Autophagy
T9721	ML339		CXCR
	ML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.		CXCR
T4033	MSX-130	MSX 130	CXCR
	MSX-130 is CXCR4 Antagonist.		CXCR
T4032	MSX-127	MSX 127	CXCR
	MSX-127 elicites positive response in peptide CXCR4.		CXCR
TQ0174	Mavorixafor	AMD-070	CXCR
	Mavorixafor (AMD-070) is an effective and selective antagonist of CXCR4, with an IC50 value of 13 nM against CXCR4 125I-SDF binding. Mavorixafor inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells (IC...		CXCR
T7499	TAK-779	Takeda 779	HIV Protease , CXCR , CCR
	TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).		HIV Protease , CXCR , CCR
T8497	SX-682		CXCR
	SX-682 is a potent, selective and orally bioavailable inhibitor of CXCR1/2 ,has the potential to treat castration-resistant prostate cancer.		CXCR
T16850	SB-265610	GSK-CXCR2	CXCR
	SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization and neutrophil chemotaxis (IC50s: 3.7 nM and...		CXCR
T3396	Baohuoside I	Icariside-II,Icariin-II	Apoptosis , CXCR
	Baohuoside I (Icariside-II) is a component of Epimedium koreanum, exhibits anti-inflammatory activity and anti-osteoporosis activities.		Apoptosis , CXCR
T11179	Elubrixin	SB-656933	IL Receptor , CXCR
	Elubrixin (SB-656933) inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin can be used for inflammatory diseases such as inflammatory bowel disease and airway inflammat...		IL Receptor , CXCR
T7130	Navarixin	MK-7123,SCH 527123	CXCR
	Navarixin (MK-7123)(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophil trafficking in animal models, characteristics that may be benef...		CXCR